Articles
Intralesional and subcutaneous application of Viscum album L. (European mistletoe) extract in cervical carcinoma in situ A CARE compliant case report
Author: MarÃa Reynel, Yván Villegas, Helmut Kiene, Paul G. Werthmann, Gunver S. Kienle
Carcinoma in situ (CIS), the last grade of dysplasia observed before invasive cancer, is defined as cervical intraepithelial neoplasia grade 3 (CIN 3).
Long-term tumor-free survival in a metastatic pancreatic carcinoma patient with FOLFIRINOX/ Mitomycin, high-dose, fever inducing Viscum album extracts and subsequent R0 resection
Author: Paul Georg Werthmann, Pia Inter, Thilo Welsch, Anne-Kathrin Sturm, Robert Grützmann, Markus Debus, Martin-Günther Sterner, Gunver Sophia Kienle
Pancreatic cancer (PC) is a common malignancy (incidence 12.4/100.000 in the US), with poor prognosis (5-year survival of 2%), especially in cases involving metastatic disease (a median survival of 3.7 months and 6.4 months, despite chemotherapy).
Complete remission and long-term survival of a patient with melanoma metastases treated with high-dose fever-inducing Viscum album extract
Author: Paul G. Werthmann, Alexander Hintze, Gunver S. Kienle
Malignant cutaneous melanoma (MCM) is the sixth most common of all cancers and the deadliest of all skin cancers, with increasing incidence worldwide (incidence and mortality are 9.3–10.2 and 1.2–2.0 per 100,000 people, respectively).
Minor regression and long-time survival (56 months) in a patient with malignant pleural mesothelioma under Viscum album and Helleborus niger extracts—a case report
Author: Paul G. Werthmann, Gerhard Saltzwedel, Gunver S. Kienle
Malignant pleural mesothelioma (MPM) is a rare cancer (incidence 1/100,000 in the US) and is typically linked to asbestos exposure [about 80% of all MPM cases (1)]. The prognosis is poor [median survival 7 months (2)].
Durable clinical remission of a skull metastasis under intralesional Viscum album extract therapy: Case report
Author: Paul Georg Werthmann, Roman Huber, Gunver Sophia Kienle
Metastasis to the skull is a rare event, occurring in various cancers. Although metastasis of the skull base carries the risk of cranial nerve dysfunction, metastases of the calvarian skull are mostly asymptomatic but can cause pain.
Durable Regression of Primary Cutaneous B-Cell Lymphoma Following Fever-inducing Mistletoe Treatment: Two Case Reports
Author: Maurice Orange, Aija Lace, Maria P. Fonseca, Broder H. von Laue, Stefan Geider, Gunver S. Kienle
Long-term remissions of lymphoma after fever inducing therapy with bacterial toxins have been documented since William Coley.
Disappearance of an Advanced Adenomatous Colon Polyp after Intratumoural Injection with Viscum album (European mistletoe) Extract: a Case Report
Author: Tido von Schoen-Angerer, Andreas Goyert, Jan Vagedes, Helmut Kiene, Harald Merckens, Gunver S. Kienle
Extracts of Viscum album (European mistletoe) have immune-stimulatory and cytotoxic effects, with trials showing a well-established effect on the quality of life and prolonged survival in patients with advanced pancreatic cancer.
Tumour response following high-dose intratumoural application of Viscum album on a patient with adenoid cystic carcinoma
Author:Paul Georg Werthmann, Dieter Helling, Peter Heusser, Gunver Sophia Kienle
Adenoid cystic carcinoma (ACC) is a rare type of cancer that typically originates in the salivary glands. Surgical removal can lead to functional loss and psychological distress.
Bilateral Asynchronous Renal Cell Carcinoma With Lung Metastases: A Case Report of a Patient Treated Solely With High-dose Intravenous and Subcutaneous Viscum album Extract for a Second Renal Lesion
Author: Maria Reynel, Yvan Villegas, Helmut Kiene, Paul G. Werthmann, Gunver S. Kienle
Bilateral asynchronous renal cell carcinoma (RCC) is infrequent. Immunotherapy is the first-line treatment for advanced RCC not controlled by locoregional therapy.
Complete Remission and Long-term Survival of a Patient with a Diffuse Large B-cell Lymphoma Under Viscum album Extracts After Resistance to R-CHOP: A Case Report
Author: Johannes Gutsch, Paul G. Werthmann, Andreas Rosenwald, Gunver S. Kienle
A nodular lymphocyte predominant Hodgkin’s lymphoma (NLPHL) is a lymphoproliferative neoplasm with a fair prognosis, but the possibility of a malignant transformation into a diffuse large B-cell lymphoma (DLBCL) is high.